Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


HIV-1-induced inflammation shapes innate immunity and induces adaptive traits in NK cells

Chronic inflammation associated with HIV-1 infection disrupts the homeostasis of gut-resident innate lymphoid cells and induces the generation and expansion of adaptive NK cells expressing TCF7, a transcription factor that sustains their effector functions and memory-like properties.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Fig. 1: HIV-1-associated inflammation alters the homeostasis of gut-resident and circulating lymphocytes.


  1. Zicari, S. et al. Viruses 11, E200 (2019).

    Article  Google Scholar 

  2. Wang, Y. Nat. Immunol. (2020).

  3. Alzahrani, J. et al. EBioMedicine 46, 522–531 (2019).

    Article  Google Scholar 

  4. Hunt, P. W. et al. J. Infect. Dis. 210, 1228–1238 (2014).

    Article  CAS  Google Scholar 

  5. Belkina, A. C. et al. Front. Immunol. 9, 2783 (2018).

    Article  CAS  Google Scholar 

  6. Mikulak, J., Oriolo, F., Zaghi, E., Di Vito, C. & Mavilio, D. AIDS 31, 2317–2330 (2017).

    Article  CAS  Google Scholar 

  7. Cerwenka, A. & Lanier, L. L. Nat. Rev. Immunol. 16, 112–123 (2016).

    Article  CAS  Google Scholar 

  8. Hammer, Q. et al. Nat. Immunol. 19, 453–463 (2018).

    Article  CAS  Google Scholar 

  9. Peppa, D. Front. Immunol. 8, 1322 (2017).

    Article  Google Scholar 

  10. Lucar, O., Reeves, R. K. & Jost, S. Front. Immunol. 10, 1850 (2019).

    Article  Google Scholar 

  11. Schlums, H. et al. Immunity 42, 443–456 (2015).

    Article  CAS  Google Scholar 

  12. Jeevan-Raj, B. et al. Cell Rep. 20, 613–626 (2017).

    Article  CAS  Google Scholar 

  13. Utzschneider, D. T. et al. Immunity 45, 415–427 (2016).

    Article  CAS  Google Scholar 

  14. Wang, Y. et al. Front. Immunol. 10, 169 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Domenico Mavilio.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mikulak, J., Di Vito, C. & Mavilio, D. HIV-1-induced inflammation shapes innate immunity and induces adaptive traits in NK cells. Nat Immunol 21, 245–247 (2020).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing