Highly proliferative cells have classically been thought to rely on anaerobic glycolysis for fuel. Weisel et al. show that germinal center B cells break this rule, as they primarily utilize fatty acid oxidation to meet their metabolic demands.
This is a preview of subscription content, access via your institution
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Rent or buy this article
Get just this article for as long as you need it
Prices may be subject to local taxes which are calculated during checkout
MacLennan, I. C. Annu. Rev. Immunol. 12, 117–139 (1994).
Allen, C. D., Okada, T., Tang, H. L. & Cyster, J. G. Science 315, 528–531 (2007).
Gitlin, A. D. et al. Science 349, 643–646 (2015).
Tas, J. M. et al. Science 351, 1048–1054 (2016).
Weisel, F. J. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0598-4 (2020).
Liu, Y. J. et al. Nature 342, 929–931 (1989).
Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Science 324, 1029–1033 (2009).
Victora, G. D. et al. Cell 143, 592–605 (2010).
Dominguez-Sola, D. et al. Nat. Immunol. 13, 1083–1091 (2012).
Calado, D. P. et al. Nat. Immunol. 13, 1092–1100 (2012).
Ersching, J. et al. Immunity 46, 1045–1058.e6 (2017).
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Pae, J., Victora, G.D. B is for ‘Big Mac’: GCs crave a high-fat diet. Nat Immunol 21, 249–250 (2020). https://doi.org/10.1038/s41590-020-0614-8