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B cells

B is for ‘Big Mac’: GCs crave a high-fat diet

Nature Immunology volume 21, pages 249–250 (2020)Cite this article

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Highly proliferative cells have classically been thought to rely on anaerobic glycolysis for fuel. Weisel et al. show that germinal center B cells break this rule, as they primarily utilize fatty acid oxidation to meet their metabolic demands.

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Fig. 1: Bioenergetics of germinal center B cells.

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Authors and Affiliations

  1. Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA

    Juhee Pae & Gabriel D. Victora

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  1. Juhee Pae
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  2. Gabriel D. Victora
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Correspondence to Gabriel D. Victora.

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Pae, J., Victora, G.D. B is for ‘Big Mac’: GCs crave a high-fat diet. Nat Immunol 21, 249–250 (2020). https://doi.org/10.1038/s41590-020-0614-8

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