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B cells

B is for ‘Big Mac’: GCs crave a high-fat diet

Highly proliferative cells have classically been thought to rely on anaerobic glycolysis for fuel. Weisel et al. show that germinal center B cells break this rule, as they primarily utilize fatty acid oxidation to meet their metabolic demands.

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Fig. 1: Bioenergetics of germinal center B cells.


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Correspondence to Gabriel D. Victora.

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The authors declare no competing interests.

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Pae, J., Victora, G.D. B is for ‘Big Mac’: GCs crave a high-fat diet. Nat Immunol 21, 249–250 (2020).

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