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T CELL EXHAUSTION

PAC1-ing up the epigenetic landscape

Nature Immunology volume 21, pages 247–248 (2020)Cite this article

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Oxidative stress in the tumor microenvironment activates expression of the phosphatase PAC1 in infiltrated T lymphocytes. PAC1 regulates the epigenetic modulator NuRD to limit the chromatin accessibility of T cell effector function genes, thereby fostering T cell exhaustion.

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Fig. 1: Transition to exhaustion of CD8+ T cells in the tumor microenvironment due to epigenetic remodeling induced by ROS-EGR1-PAC1.

References

  1. Wherry, E. J. & Kurachi, M. Nat. Rev. Immunol. 15, 486–499 (2015).

    Article  CAS  Google Scholar 

  2. Saeidi, A. et al. Front. Immunol. 9, 2569 (2018).

    Article  Google Scholar 

  3. Philip, M. & Schietinger, A. Curr. Opin. Immunol. 58, 98–103 (2019).

    Article  CAS  Google Scholar 

  4. Lu D. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0577-9 (2020).

  5. Png, C. W. et al. Oncogene 35, 206–217 (2016).

    Article  CAS  Google Scholar 

  6. Kidger, A. M. et al. Proc. Natl Acad. Sci. USA 114, E317–E326 (2017).

    Article  CAS  Google Scholar 

  7. Low, H. B. & Zhang, Y. Immune. Netw. 16, 85–98 (2016).

    Article  Google Scholar 

  8. Weinberg, F., Ramnath, N. & Nagrath, D. Cancers (Basel) 11, E1191 (2019).

    Article  Google Scholar 

  9. Fisicaro, P. et al. Nat. Med. 23, 327–336 (2017).

    Article  CAS  Google Scholar 

  10. Bracken, A. P., Brien, G. L. & Verrijzer, C. P. Genes Dev. 33, 936–959 (2019).

    Article  CAS  Google Scholar 

  11. Liang, Z. et al. A high-resolution map of transcriptional repression. Elife 6, e22767 (2017).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Sze Chun Leo Chan & Yongliang Zhang

  2. Immunology Programme, the Life Science Institute, National University of Singapore, Singapore, Singapore

    Sze Chun Leo Chan & Yongliang Zhang

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  1. Sze Chun Leo Chan
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  2. Yongliang Zhang
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Correspondence to Yongliang Zhang.

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The authors declare no competing interests.

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Chan, S.C.L., Zhang, Y. PAC1-ing up the epigenetic landscape. Nat Immunol 21, 247–248 (2020). https://doi.org/10.1038/s41590-020-0594-8

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