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IMMUNOMETABOLISM

Mitochondria orchestrate T cell fate and function

An investigation of the molecular processes of mitochondrial reprogramming and metabolic stress in antigen-experienced T cells within tumor microenvironments reveals mechanisms responsible for T cell exhaustion and dysfunction and facilitates the development of new strategies for tumor immunotherapy.

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Fig. 1: Mitochondrial reprogramming for the development of exhausted T cells within the tumor microenvironment.

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Correspondence to Guangyong Peng.

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Liu, X., Peng, G. Mitochondria orchestrate T cell fate and function. Nat Immunol 22, 276–278 (2021). https://doi.org/10.1038/s41590-020-00861-6

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