Single-cell-sequencing techniques enable the decades-old T helper subset dogma to be re-examined in an unsupervised manner, bringing nuance to the definition of known subsets while simultaneously identifying interesting new cell states.
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Acknowledgements
E.L. is funded by grants from the European Research Council (ERC-StG-2014 PERSYST 640511) and by the Associazione Italiana per la Ricerca sul Cancro (AIRC IG 20676 and AIRC 5x1000 UniCanVax 22757). M.R. is funded by grants from the European Research Council (ERC_CoG 615735 Homeogut), AIRC IG 22026 2018 and AIRC 5x1000 UniCanVax 22757.
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van Beek, J.J.P., Rescigno, M. & Lugli, E. A fresh look at the T helper subset dogma. Nat Immunol 22, 104–105 (2021). https://doi.org/10.1038/s41590-020-00858-1
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DOI: https://doi.org/10.1038/s41590-020-00858-1
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