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Complement inhibitor for therapy of CHAPLE

A new study shows successful immunotherapy of a detrimental gastrointestinal disease using the complement inhibitor eculizumab.

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Fig. 1: Activation and regulation of complement pathways.


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The authors are supported by a National Institute of Arthritis Musculoskeletal and Skin Disease grant (R01 AR073311) from the National Institutes of Health.

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Correspondence to Chack-Yung Yu or Stacy P. Ardoin.

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The authors declare no competing interests.

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Yu, CY., Ardoin, S.P. Complement inhibitor for therapy of CHAPLE. Nat Immunol 22, 106–108 (2021).

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