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A new cell subtype that confers neuroprotection

A subset of neutrophils with an immature phenotype confers neuroprotection in traumatic optic nerve and spinal cord injury. This study identifies a new target population of cells for therapeutic strategies to induce neural regeneration during injury.

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Fig. 1: Mature ‘N1’ neutrophils confer neurodegeneration, while immature ‘N2’ neutrophils induce neuroregeneration.


  1. Sas, A. R. et al. Nat. Immunol. (2020).

  2. Miron, V. E. et al. Nat. Neurosci. 16, 1211–1218 (2013).

    Article  CAS  Google Scholar 

  3. Ruckh, J. M. et al. Cell Stem Cell 10, 96–103 (2012).

    Article  CAS  Google Scholar 

  4. Moyon, S. et al. J. Neurosci. 35, 4–20 (2015).

    Article  Google Scholar 

  5. Voskuhl, R. R. et al. Proc. Natl Acad. Sci. USA 116, 10130–10139 (2019).

    Article  CAS  Google Scholar 

  6. Bookheimer, S. Y. et al. Neuroimage 185, 335–348 (2019).

    Article  Google Scholar 

  7. Chai, H. et al. Neuron 95, 531–549.e9 (2017).

    Article  CAS  Google Scholar 

  8. Khakh, B. S. & Sofroniew, M. V. Nat. Neurosci. 18, 942–952 (2015).

    Article  CAS  Google Scholar 

  9. Grabert, K. et al. Nat. Neurosci. 19, 504–516 (2016).

    Article  CAS  Google Scholar 

  10. Marques, S. et al. Science 352, 1326–1329 (2016).

    Article  CAS  Google Scholar 

  11. Itoh, N. et al. Proc. Natl Acad. Sci. USA 115, E302–E309 (2018).

    Article  CAS  Google Scholar 

  12. Tassoni, A. et al. Sci. Rep. 9, 10010 (2019).

    Article  Google Scholar 

  13. Yan, Z. et al. JCI Insight 5, e126520 (2019).

    Article  Google Scholar 

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Correspondence to Rhonda Voskuhl.

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Voskuhl, R. A new cell subtype that confers neuroprotection. Nat Immunol 21, 1477–1478 (2020).

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