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‘Bohemian Rhapsody’ of MR1T cells

A T cell recognizing the MHC class I–related molecule MR1, expressed by a wide range of cancer cell types, might have great potential for adoptive cell therapy in cancer.

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Fig. 1: Broad tumor recognition by MR1T cells.


  1. Crowther, M. D. et al. Nat. Immunol. (2019).

    Article  Google Scholar 

  2. Porcelli, S., Yockey, C. E., Brenner, M. B. & Balk, S. P. J. Exp. Med. 178, 1–16 (1993).

    Article  CAS  Google Scholar 

  3. Tilloy, F. et al. J. Exp. Med. 189, 1907–1921 (1999).

    Article  CAS  Google Scholar 

  4. Treiner, E. et al. Nature 422, 164–169 (2003).

    Article  CAS  Google Scholar 

  5. Reantragoon, R. et al. J. Exp. Med. 210, 2305–2320 (2013).

    Article  CAS  Google Scholar 

  6. Gold, M. C. et al. J. Exp. Med. 211, 1601–1610 (2014).

    Article  CAS  Google Scholar 

  7. Lepore, M. et al. Nat. Commun. 5, 3866 (2014).

    Article  Google Scholar 

  8. Kjer-Nielsen, L. et al. Nature 491, 717–723 (2012).

    Article  CAS  Google Scholar 

  9. Corbett, A. J. et al. Nature 509, 361–365 (2014).

    Article  CAS  Google Scholar 

  10. Meermeier, E. W. et al. Nat. Commun. 7, 12506 (2016).

    Article  CAS  Google Scholar 

  11. Gherardin, N. A. et al. Immunity 44, 32–45 (2016).

    Article  CAS  Google Scholar 

  12. Koay, H. F. et al. Nat. Commun. 10, 2243 (2019).

    Article  Google Scholar 

  13. Lepore, M. et al. eLife 6, e24476 (2017).

    Article  Google Scholar 

  14. Lepore, M., Mori, L. & De Libero, G. Front. Immunol. 9, 1365 (2018).

    Article  Google Scholar 

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Correspondence to Lucia Mori.

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The University of Basel has filed a patent on MR1T cells.

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Mori, L., De Libero, G. ‘Bohemian Rhapsody’ of MR1T cells. Nat Immunol 21, 108–110 (2020).

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