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TUMOR IMMUNOLOGY

Fragility can be a good thing in cancer

IL-33 is shown to play a cell-intrinsic role in maintenance of the functional identity of regulatory T cells in the tumor microenvironment. Genetic inhibition of IL-33 potentiates the therapeutic effect of checkpoint inhibitor immunotherapy in a melanoma mouse tumor model.

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Fig. 1: An intrinsic role for IL-33 in the pro-tumorigenic function of Treg cells.

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Correspondence to Rudi Beyaert.

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Demeyer, A., Beyaert, R. Fragility can be a good thing in cancer. Nat Immunol 21, 11–13 (2020). https://doi.org/10.1038/s41590-019-0564-1

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