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Specificity meets function

Specificity and function are the two main aspects that define T cell biology. A new report provides a technology that allows simultaneous assessment of both at the single-cell level.

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Fig. 1: Method for simultaneously determining T cell specificity and T cell function, and the applicability of this method.


  1. Tu, A.A. et al. Nat. Immunol. (2019).

  2. Han, A., Glanville, J., Hansmann, L. & Davis, M. M. Nat. Biotechnol. 32, 684–692 (2014).

    Article  CAS  Google Scholar 

  3. Li, B. et al. Nat. Genet. 48, 725–732 (2016).

    Article  CAS  Google Scholar 

  4. Stubbington, M. J. T. et al. Nat. Methods 13, 329–332 (2016).

    Article  Google Scholar 

  5. Dash, P. et al. J. Clin. Invest. 121, 288–295 (2011).

    Article  CAS  Google Scholar 

  6. Macosko, E. Z. et al. Cell 161, 1202–1214 (2015).

    Article  CAS  Google Scholar 

  7. Klein, A. M. et al. Cell 161, 1187–1201 (2015).

    Article  CAS  Google Scholar 

  8. Gierahn, T. M. et al. Nat. Methods 14, 395–398 (2017).

    Article  CAS  Google Scholar 

  9. Singh, M. et al. Nat. Commun. 10, 3120 (2019).

  10. Saikia, M. et al. Nat. Meth. 16, 59–62 (2019).

  11. Zemmour, D. et al. Nat. Immunol. 19, 291–301 (2018).

    Article  CAS  Google Scholar 

  12. Gupta, I. et al. Nat. Biotechnol. 36, 1197–1202 (2018).

    Article  CAS  Google Scholar 

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Correspondence to Joachim L. Schultze.

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Schultze, J.L. Specificity meets function. Nat Immunol 20, 1565–1567 (2019).

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