Extended Data Fig. 1: oxPAPC drives hyperactivation and hypermetabolism in macrophages. | Nature Immunology

Extended Data Fig. 1: oxPAPC drives hyperactivation and hypermetabolism in macrophages.

From: Endogenous oxidized phospholipids reprogram cellular metabolism and boost hyperinflammation

Extended Data Fig. 1

Schematic depicting oxPAPC activities. oxPAPC is a mixture of oxidized phospholipids that induce an hyperinflammatory state in phagocytes upon LPS encounter and/or during atherosclerosis development. Moieties such as POVPC or PGPC contained in oxPAPC drive the formation of hyperactive cells that are characterized by inflammasome activation in the absence of pyroptosis. In contrast to POVPC or PGPC, PEIPC engages a hypermetabolic state in phagocytes that favors IL-1β accumulation and that is characterized by: i) the simultaneous activation of OXPHOS and aerobic glycolysis; ii) glutamine utilization to feed the TCA cycle; iii) oxaloacetate (OAA) accumulation in the cytoplasm to potentiate HIF-1α activation.

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