INTESTINAL VIROME

Viruses RIG up intestinal immunity

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The virome, increasingly recognized as a critical component of the mammalian microbiota, modulates host physiology. An antiviral treatment approach reveals that, via RIG-I signaling, the commensal virome is essential for the homeostasis of intestinal intraepithelial lymphocytes.

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Fig. 1: RIG-I-mediated sensing of commensal viruses stimulates IEL homeostasis.

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Correspondence to Megan T. Baldridge.

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Lee, S., Baldridge, M.T. Viruses RIG up intestinal immunity. Nat Immunol 20, 1563–1564 (2019) doi:10.1038/s41590-019-0530-y

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