NKT CELLS

What one lipid giveth, another taketh away

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Acid sphingomyelinase deficiency, which prevents degradation of sphingomyelin (SM), causes lysosomal SM overload both in mice and in patients with Niemann–Pick disease A or B. Altered cellular SM homeostasis disrupts the development and function of natural killer T cells by obstructing the presentation of lipid agonists by CD1d molecules.

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Fig. 1: ASM deficiency affects CD1d and NKT cell functions.

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Correspondence to Sebastian Joyce.

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Joyce, S., Spiller, B.W. & Van Kaer, L. What one lipid giveth, another taketh away. Nat Immunol 20, 1559–1561 (2019) doi:10.1038/s41590-019-0525-8

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