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NKT CELLS

What one lipid giveth, another taketh away

Nature Immunology volume 20, pages 1559–1561 (2019)Cite this article

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Acid sphingomyelinase deficiency, which prevents degradation of sphingomyelin (SM), causes lysosomal SM overload both in mice and in patients with Niemann–Pick disease A or B. Altered cellular SM homeostasis disrupts the development and function of natural killer T cells by obstructing the presentation of lipid agonists by CD1d molecules.

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Fig. 1: ASM deficiency affects CD1d and NKT cell functions.

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Authors and Affiliations

  1. Department of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN, USA

    Sebastian Joyce

  2. Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Sebastian Joyce & Luc Van Kaer

  3. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA

    Benjamin W. Spiller

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  1. Sebastian Joyce
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  2. Benjamin W. Spiller
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  3. Luc Van Kaer
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Correspondence to Sebastian Joyce.

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Joyce, S., Spiller, B.W. & Van Kaer, L. What one lipid giveth, another taketh away. Nat Immunol 20, 1559–1561 (2019). https://doi.org/10.1038/s41590-019-0525-8

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