Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

MECHANOSENSING

Monocytes work harder under pressure

Nature Immunology volume 20, pages 1422–1424 (2019)Cite this article

Subjects

The mechano-sensitive membrane channel PIEZO1 coordinates immune defense in the lungs.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Role of pressure sensing in lung immunity.

References

  1. Coste, B. et al. Science 330, 55–60 (2010).

    Article  CAS  Google Scholar 

  2. Murthy, S. E., Dubin, A. E. & Patapoutian, A. Nat. Rev. Mol. Cell Biol. 18, 771–783 (2017).

    Article  CAS  Google Scholar 

  3. Solis, A. G. et al. Nature 573, Nature 69–74 (2019).

  4. Huse, M. Nat. Rev. Immunol. 17, 679–690 (2017).

    Article  CAS  Google Scholar 

  5. Maruyama, K., Nemoto, E. & Yamada, S. Inflamm. Regen. 39, 3 (2019).

    Article  Google Scholar 

  6. Wang, L. et al. Nature 573, 225–229 (2019).

    Article  CAS  Google Scholar 

  7. Zhao, Q. et al. Nature 554, 487–492 (2018).

    Article  CAS  Google Scholar 

  8. Saotome, K. et al. Nature 554, 481–486 (2018).

    Article  CAS  Google Scholar 

  9. Lin, Y.-C. et al. Nature 573, 230–234 (2019).

    Article  CAS  Google Scholar 

  10. Kowalczyk, A., Kleniewska, P., Kolodziejczyk, M., Skibska, B. & Goraca, A. Arch. Immunol. Ther. Exp. (Warsz. ) 63, 41–52 (2015).

    Article  CAS  Google Scholar 

  11. Tannahill, G. M. et al. Nature 496, 238–242 (2013).

    Article  CAS  Google Scholar 

  12. Izquierdo, H. M. et al. Cell Rep. 24, 1738–1746 (2018).

    Article  CAS  Google Scholar 

  13. Li, C. et al. Sci. Rep. 8, 3603 (2018).

    Article  Google Scholar 

  14. Svedberg, F. R. et al. Nat. Immunol. 20, 571–580 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Francis Crick Institute, London, UK

    Pavel Tolar & Andreas Wack

Authors
  1. Pavel Tolar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andreas Wack
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Pavel Tolar or Andreas Wack.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tolar, P., Wack, A. Monocytes work harder under pressure. Nat Immunol 20, 1422–1424 (2019). https://doi.org/10.1038/s41590-019-0523-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-019-0523-x

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing