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TCR ACTIVATION

Slow phosphor-Y-LAT-ion for TCR ligand discrimination

Nature Immunology volume 20, pages 1420–1422 (2019)Cite this article

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A report sheds new light on the molecular mechanisms responsible for the discrimination of self versus non-self TCR ligands and reveals the crucial role of the kinetics of LAT tyrosine phosphorylation in this.

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Fig. 1: The kinetics with which the sixth tyrosine of LAT is phosphorylated control the discrimination of TCR ligands.

References

  1. Lo, W.-L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0502-2 (2019).

    Article  PubMed  Google Scholar 

  2. McKeithan, T. W. Proc. Natl Acad. Sci. USA 92, 5042–5046 (1995).

    Article  CAS  Google Scholar 

  3. Irvine, D. J., Purbhoo, M. A., Krogsgaard, M. & Davis, M. M. Nature 419, 845–849 (2002).

    Article  CAS  Google Scholar 

  4. Yousefi, O. S. et al. eLife 8, e42475 (2019).

    Article  Google Scholar 

  5. Dushek, O. & van der Merwe, P. A. Trends Immunol. 35, 153–158 (2014).

    Article  CAS  Google Scholar 

  6. Stepanek, O. et al. Cell 159, 333–345 (2014).

    Article  CAS  Google Scholar 

  7. Malissen, B., Aguado, E. & Malissen, M. Adv. Immunol. 87, 1–25 (2005).

    Article  CAS  Google Scholar 

  8. Shah, N. H. et al. eLife 5, e20105 (2016).

    Article  Google Scholar 

  9. Houtman, J. C., Houghtling, R. A., Barda-Saad, M., Toda, Y. & Samelson, L. E. J. Immunol. 175, 2449–2458 (2005).

    Article  CAS  Google Scholar 

  10. Courtney, A. H. et al. Mol. Cell 67, 498–511 (2017).

    Article  CAS  Google Scholar 

  11. Lo, W. L. et al. Nat. Immunol. 19, 733–741 (2018).

    Article  CAS  Google Scholar 

  12. Arbulo-Echevarria, M. M. et al. Front. Immunol. 9, 115 (2018).

    Article  Google Scholar 

  13. Valdor, R. & Macian, F. Semin. Immunol. 25, 313–320 (2013).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Biomedical Research Cadiz (INIBICA), Cádiz, Spain

    Enrique Aguado & Mikel M. Arbulo-Echevarria

  2. Department of Biomedicine, Biotechnology and Public Health (Immunology), University of Cádiz, Cádiz, Spain

    Enrique Aguado

Authors
  1. Enrique Aguado
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  2. Mikel M. Arbulo-Echevarria
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Correspondence to Enrique Aguado.

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The authors declare no competing interests.

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Aguado, E., Arbulo-Echevarria, M.M. Slow phosphor-Y-LAT-ion for TCR ligand discrimination. Nat Immunol 20, 1420–1422 (2019). https://doi.org/10.1038/s41590-019-0522-y

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