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TCR ACTIVATION

Slow phosphor-Y-LAT-ion for TCR ligand discrimination

A report sheds new light on the molecular mechanisms responsible for the discrimination of self versus non-self TCR ligands and reveals the crucial role of the kinetics of LAT tyrosine phosphorylation in this.

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Fig. 1: The kinetics with which the sixth tyrosine of LAT is phosphorylated control the discrimination of TCR ligands.

References

  1. Lo, W.-L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0502-2 (2019).

    Article  PubMed  Google Scholar 

  2. McKeithan, T. W. Proc. Natl Acad. Sci. USA 92, 5042–5046 (1995).

    Article  CAS  Google Scholar 

  3. Irvine, D. J., Purbhoo, M. A., Krogsgaard, M. & Davis, M. M. Nature 419, 845–849 (2002).

    Article  CAS  Google Scholar 

  4. Yousefi, O. S. et al. eLife 8, e42475 (2019).

    Article  Google Scholar 

  5. Dushek, O. & van der Merwe, P. A. Trends Immunol. 35, 153–158 (2014).

    Article  CAS  Google Scholar 

  6. Stepanek, O. et al. Cell 159, 333–345 (2014).

    Article  CAS  Google Scholar 

  7. Malissen, B., Aguado, E. & Malissen, M. Adv. Immunol. 87, 1–25 (2005).

    Article  CAS  Google Scholar 

  8. Shah, N. H. et al. eLife 5, e20105 (2016).

    Article  Google Scholar 

  9. Houtman, J. C., Houghtling, R. A., Barda-Saad, M., Toda, Y. & Samelson, L. E. J. Immunol. 175, 2449–2458 (2005).

    Article  CAS  Google Scholar 

  10. Courtney, A. H. et al. Mol. Cell 67, 498–511 (2017).

    Article  CAS  Google Scholar 

  11. Lo, W. L. et al. Nat. Immunol. 19, 733–741 (2018).

    Article  CAS  Google Scholar 

  12. Arbulo-Echevarria, M. M. et al. Front. Immunol. 9, 115 (2018).

    Article  Google Scholar 

  13. Valdor, R. & Macian, F. Semin. Immunol. 25, 313–320 (2013).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Enrique Aguado.

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Aguado, E., Arbulo-Echevarria, M.M. Slow phosphor-Y-LAT-ion for TCR ligand discrimination. Nat Immunol 20, 1420–1422 (2019). https://doi.org/10.1038/s41590-019-0522-y

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