STING ACTIVATION

A carrier for cyclic dinucleotides

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Cyclic dinucleotides (CDNs) are potent activators of the innate immune sensor STING. The identification of a CDN importer sheds new light on the regulation of extracellular CDNs.

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Fig. 1: Transport of extracellular CDNs.

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Author information

Correspondence to Andrea Ablasser.

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Competing interests

A.A. is a shareholder in a company that is developing STING- and cGAS-directed therapeutics.

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Guey, B., Ablasser, A. A carrier for cyclic dinucleotides. Nat Immunol 20, 1418–1420 (2019) doi:10.1038/s41590-019-0521-z

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