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STING ACTIVATION

A carrier for cyclic dinucleotides

Nature Immunology volume 20, pages 1418–1420 (2019)Cite this article

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Cyclic dinucleotides (CDNs) are potent activators of the innate immune sensor STING. The identification of a CDN importer sheds new light on the regulation of extracellular CDNs.

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Fig. 1: Transport of extracellular CDNs.

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Authors and Affiliations

  1. Global Health Institute, Swiss Federal Institute of Technology, Lausanne, Switzerland

    Baptiste Guey & Andrea Ablasser

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  1. Baptiste Guey
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  2. Andrea Ablasser
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Correspondence to Andrea Ablasser.

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Competing interests

A.A. is a shareholder in a company that is developing STING- and cGAS-directed therapeutics.

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Guey, B., Ablasser, A. A carrier for cyclic dinucleotides. Nat Immunol 20, 1418–1420 (2019). https://doi.org/10.1038/s41590-019-0521-z

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