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TISSUE-RESIDENT T CELLS

The highs and lows of CD4+ tissue-resident T cells in lung fibrosis

Nature Immunology volume 20, pages 1416–1418 (2019)Cite this article

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Chronic exposure to fungal antigen drives the development of two subsets of CD4+ TRM cells, distinguished by high or low expression of the integrin CD103, with opposing roles in inflammation-induced lung fibrosis.

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Fig. 1: CD103hi tissue-resident Treg cells control fibrotic responses elicited by CD103lo pathogenic CD4+ TRM cells in the lungs.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia

    Maximilien Evrard & Laura K. Mackay

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  1. Maximilien Evrard
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  2. Laura K. Mackay
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Correspondence to Laura K. Mackay.

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Evrard, M., Mackay, L.K. The highs and lows of CD4+ tissue-resident T cells in lung fibrosis. Nat Immunol 20, 1416–1418 (2019). https://doi.org/10.1038/s41590-019-0501-3

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