Cellular metabolic screening identifies hyper-respiration, induced by gain-of-function mutations in the gene encoding succinate dehydrogenase, as a disease-driving immunometabolic trait of B cells from patients with primary antibody deficiency.
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Zeng, H., Chi, H. Metabolic sleuthing solves a rare immunodeficiency disease. Nat Immunol 20, 1264–1266 (2019). https://doi.org/10.1038/s41590-019-0499-6
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DOI: https://doi.org/10.1038/s41590-019-0499-6
