TH17 cell flavors

Immunity (2019)

The TH17 subset of helper T cells is pathogenic in a variety of inflammatory disorders but also has tissue-resident homeostatic roles in the intestine. In Immunity, Omenetti et al. compare the characteristics of TH17 cells induced by commensal microbiota, notably segmented filamentous bacteria (SFB), and those elicited by a pathogen (Citrobacter rodentium). Secretion of the cytokine IL-17A is higher in SFB-induced TH17 cells, the cytokine IFN-γ is more abundant in C. rodentium–elicited TH17 cells, and both groups of cells produce IL-22. SFB-induced TH17 cells do not expand in response to infection with C. rodentium. RNA-sequencing analysis indicates enrichment for transcripts encoding molecules involved in anti-inflammatory pathways and oxidative phosphorylation in SFB-induced TH17 cells and enrichment for markers of glycolysis, biosynthesis and pro-inflammatory pathways in C. rodentium–elicited TH17 cells. These results indicate that two functionally distinct populations of TH17 cells can reside in the gut simultaneously during pathogen-induced inflammation.

Author information

Correspondence to Ioana Visan.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Visan, I. TH17 cell flavors. Nat Immunol 20, 945 (2019).

Download citation