Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

CELLULAR IMMUNOTHERAPIES

At the end of the beginning: immunotherapies as living drugs

An Author Correction to this article was published on 06 August 2019

This article has been updated

The American Course on Drug Development and Regulatory Science and the US National Institutes of Health held a workshop on cell-based immunotherapy on 22 January 2019.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: CAR-T therapy.
Fig. 2: Approaches in various stages of development.
Fig. 3: Duration of remission, event-free survival, and overall survival of pediatric and young-adult patients with ALL given infusion of Kymriah.

Change history

  • 06 August 2019

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

References

  1. 1.

    Mezher, M. Regulatory Affairs Professional Society https://www.raps.org/news-and-articles/news-articles/2019/1/gottlieb-marks-detail-plans-to-advance-developmen?utm_source=MagnetMail&utm_medium=Email%20&utm_campaign=Focus%20on%20Biotech%3A%20January (2019).

  2. 2.

    Sadelain, M. Cell 171, 1471 (2017).

    CAS  Article  Google Scholar 

  3. 3.

    Maude, S. L. et al. N. Engl. J. Med. 378, 439–448 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Maude, S. L. et al. N. Engl. J. Med. 371, 1507–1517 (2014).

    Article  Google Scholar 

  5. 5.

    Grupp, S.A. 60th American Society of Hematology Annual Meeting, abstr. 895 (2018).

  6. 6.

    Cherkasova, E., Weisman, Q. & Childs, R. W. Front. Oncol. 3, 243 (2013).

    Article  Google Scholar 

  7. 7.

    Takahashi, Y. et al. J. Clin. Invest. 118, 1099–1109 (2008).

    CAS  Article  Google Scholar 

  8. 8.

    Porter, D. L. et al. Sci. Transl. Med. 7, 303ra139 (2015).

    Article  Google Scholar 

  9. 9.

    Lee, D. W. et al. Biol. Blood Marrow Transplant. 25, 625–638 (2019).

    CAS  Article  Google Scholar 

  10. 10.

    Maude, S. L., Barrett, D., Teachey, D. T. & Grupp, S. A. Cancer J. 20, 119–122 (2014).

    CAS  Article  Google Scholar 

  11. 11.

    Teachey, D. T. et al. Cancer Discov. 6, 664–679 (2016).

    CAS  Article  Google Scholar 

  12. 12.

    Grupp, S. A. et al. N. Engl. J. Med. 368, 1509–1518 (2013).

    CAS  Article  Google Scholar 

  13. 13.

    Vodnala, S.K. et al. Science 363, (2019).

  14. 14.

    Rosenberg, S. A. & Restifo, N. P. Science 348, 62–68 (2015).

    CAS  Article  Google Scholar 

  15. 15.

    Gattinoni, L., Klebanoff, C. A. & Restifo, N. P. Nat. Rev. Cancer 12, 671–684 (2012).

    CAS  Article  Google Scholar 

  16. 16.

    Gautam, S. et al. Nat. Immunol. 20, 337–349 (2019).

    CAS  Article  Google Scholar 

  17. 17.

    Sade-Feldman, M. et al. Cell 175, 998–1013.e20 (2018).

    CAS  Article  Google Scholar 

  18. 18.

    Eyquem, J. et al. Nature 543, 113–117 (2017).

    CAS  Article  Google Scholar 

  19. 19.

    Ellis, J. Hum. Gene Ther. 16, 1241–1246 (2005).

    CAS  Article  Google Scholar 

  20. 20.

    Rivière, I., Dunbar, C. E. & Sadelain, M. Blood 119, 1107–1116 (2012).

    Article  Google Scholar 

  21. 21.

    von Kalle, C., Deichmann, A. & Schmidt, M. Hum. Gene Ther. 25, 475–481 (2014).

    Article  Google Scholar 

  22. 22.

    Xu, Z., Park, Y., Zhen, B. & Zhu, B. Stat. Med. 37, 4589–4609 (2018).

    Article  Google Scholar 

  23. 23.

    Xu, Z., Zhen, B., Park, Y. & Zhu, B. Stat. Med. 36, 592–605 (2017).

    Article  Google Scholar 

  24. 24.

    Tran, E., Robbins, P. F. & Rosenberg, S. A. Nat. Immunol. 18, 255–262 (2017).

    CAS  Article  Google Scholar 

  25. 25.

    Cafri, G. et al. Nat. Commun. 10, 449 (2019).

    Article  Google Scholar 

  26. 26.

    Flying machines which do not fly. The New York Times https://newspaperarchive.com/new-york-times-oct-09-1903-p-6/ (1903).

  27. 27.

    Wright, O. Diaries and Notebooks: Orville Wright. Library of Congress https://www.loc.gov/item/wright002238/ (1903).

Download references

Acknowledgements

We thank all the speakers, panelists, and organizers who made this workshop possible: Greg Campbell (GCStat Consulting), Cathy Cantilena (NIH), Natalie DeWitt (Accendo Scientific and NDA Partners), David DiGiusto (Semma Therapeutics), Jaikumar Duraiswamy (OTAT, FDA), Ellen Feigal (NDA Partners and Arizona State University), Thomas Fellner (Lonza Pharma & Biotech), Brett Giroir (US Department of Health and Human Services) Stephan Grupp (CHOP), Jaime Kenyon (American Course on Drug Development and Regulatory Science and the University of California, San Francisco), Harvey Klein (NIH), Telba Irony (CBER, FDA), Roger Kurlander (CBER, FDA), Crystal Mackall (Stanford University), Jorge-Mansilla-Soto (Memorial Sloan Kettering Cancer Center), Peter Marks (CBER, FDA), Carl Peck (NDA Partners and the University of California, San Francisco), Nicholas Restifo (NCI), Steven Rosenberg (NCI), Nirali Shah (NCI), David Stroncek (NIH), and Allen Wensky (OTAT, FDA, CBER). The full list of speakers and ‘slide decks’ for most of the presentations are on the website of the University of California, San Francisco, American Course on Drug Development and Regulatory Science (https://pharm.ucsf.edu/acdrs/events/acdrs-nih-workshop-cell-based-immunotherapy-bench-bedside-beyond).

Author information

Affiliations

Authors

Corresponding author

Correspondence to Ellen G. Feigal.

Ethics declarations

Competing interests

E.G.F. directs the Biologics Practice at NDA Partners and is on the board of directors of the ARM Foundation for Cell and Gene Medicine.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Feigal, E.G., DeWitt, N.D., Cantilena, C. et al. At the end of the beginning: immunotherapies as living drugs. Nat Immunol 20, 955–962 (2019). https://doi.org/10.1038/s41590-019-0452-8

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing