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HIV RESPONSES

CD4+ T cell signatures in HIV infection

Analysis of the whole-genome transcriptional activity of HIV-specific CD4+ T cells demonstrates distinct profiles associated with natural control of HIV replication, as well as dysfunctional phenotypes that persist even after effective antiretroviral therapy.

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Fig. 1: Distinct CD4+ T cell signatures in blood in treated and untreated HIV infection.

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Correspondence to Sharon R. Lewin.

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Gubser, C., Pitman, M.C. & Lewin, S.R. CD4+ T cell signatures in HIV infection. Nat Immunol 20, 948–950 (2019). https://doi.org/10.1038/s41590-019-0447-5

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