Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

SYSTEMIC LUPUS ERYTHEMATOSUS

‘-Omics’ shed light on B cells in lupus

Epigenetic and transcriptional analyses of B cell subsets from patients with systemic lupus erythematosus reveal extensive effects of the disease environment and identify previously unknown connections and regulators of DN2 B cells and ABC-like cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Hierarchical relationships of peripheral B cells subsets in patients with SLE.

References

  1. Liu, Z. & Davidson, A. Nat. Med. 18, 871–882 (2012).

    Article  Google Scholar 

  2. Rubtsova, K., Rubtsov, A. V., Cancro, M. P. & Marrack, P. J. Immunol. 195, 1933–1937 (2015).

    Article  CAS  Google Scholar 

  3. Myles, A., Sanz, I. & Cancro, M. P. Curr. Opin. Immunol. 57, 40–45 (2019).

    Article  CAS  Google Scholar 

  4. Scharer, C.D. Nat. Immunol. https://doi.org/10.1038/s41590-019-0419-9 (2019).

  5. Rubtsov, A. V. et al. Blood 118, 1305–1315 (2011).

    Article  CAS  Google Scholar 

  6. Rubtsova, K. et al. J. Clin. Invest. 127, 1392–1404 (2017).

    Article  Google Scholar 

  7. Manni, M. et al. Nat. Immunol. 19, 407–419 (2018).

    Article  CAS  Google Scholar 

  8. Karnell, J. L. et al. Cell. Immunol. 321, 40–45 (2017).

    Article  CAS  Google Scholar 

  9. Jenks, S. A. et al. Immunity 49, 725–739.e726 (2018).

    Article  CAS  Google Scholar 

  10. Wang, S. et al. Nat. Commun. 9, 1758 (2018).

    Article  Google Scholar 

  11. Tipton, C. M. et al. Nat. Immunol. 16, 755–765 (2015).

    Article  CAS  Google Scholar 

  12. Der, E. et al. Nat. Immunol. 20, 915–927 (2019).

    Article  CAS  Google Scholar 

  13. Arazi, A. Nat. Immunol. 20, 902–914 (2019).

    Article  CAS  Google Scholar 

  14. Zhang, F. et al. Nat. Immunol. 20, 928–942 (2019).

    Article  Google Scholar 

  15. Kuo, D. et al. Sci. Transl. Med. 11, eaau8587 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alessandra B. Pernis.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Pernis, A.B., Ivashkiv, L.B. ‘-Omics’ shed light on B cells in lupus. Nat Immunol 20, 946–948 (2019). https://doi.org/10.1038/s41590-019-0446-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-019-0446-6

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing