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INNATE IMMUNITY

TREM1-ors shake the brain and gut after stroke

A new report shows that upregulation of the receptor TREM1 on macrophages and neutrophils, dependent on the adrenergic nervous system, links stroke to systemic inflammation and gut barrier dysfunction, which result in bacterial translocation and exacerbation of neurological damage.

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Fig. 1: Stroke-induced alterations to the TREM1–TREM2 balance of innate immunity and associated gut-barrier dysfunction with subsequent infectious and organ complications.

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Correspondence to Markus Huber-Lang.

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Roselli, F., Huber-Lang, M. TREM1-ors shake the brain and gut after stroke. Nat Immunol 20, 950–952 (2019). https://doi.org/10.1038/s41590-019-0443-9

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