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INNATE IMMUNITY

TREM1-ors shake the brain and gut after stroke

Nature Immunology volume 20, pages 950–952 (2019)Cite this article

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A new report shows that upregulation of the receptor TREM1 on macrophages and neutrophils, dependent on the adrenergic nervous system, links stroke to systemic inflammation and gut barrier dysfunction, which result in bacterial translocation and exacerbation of neurological damage.

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Fig. 1: Stroke-induced alterations to the TREM1–TREM2 balance of innate immunity and associated gut-barrier dysfunction with subsequent infectious and organ complications.

References

  1. Liu, Q. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0421-2 (2019).

  2. Owens, R. et al. Front. Cell. Neurosci. 11, 56 (2017).

    PubMed  PubMed Central  Google Scholar 

  3. Keren-Shaul, H. et al. Cell 169, 1276–1290.e17 (2017).

    Article  CAS  Google Scholar 

  4. Huang, J. et al. Science 285, 595–599 (1999).

    Article  CAS  Google Scholar 

  5. Joy, M. T. et al. Cell 176, 1143–1157.e13 (2019).

    Article  CAS  Google Scholar 

  6. Jolly, L. et al. Cardiovasc. Res. 114, 907–918 (2018).

    Article  CAS  Google Scholar 

  7. Szigeti, K. et al. J. Cereb. Blood Flow Metab. 35, 1921–1929 (2015).

    Article  Google Scholar 

  8. Stanley, D. et al. Nat. Med. 22, 1277–1284 (2016).

    Article  CAS  Google Scholar 

  9. Cuvier, V. et al. Br. J. Clin. Pharmacol. 84, 2270–2279 (2018).

    Article  CAS  Google Scholar 

  10. Rasid, O. & Cavaillon, J. M. Microbes Infect. 20, 156–165 (2018).

    Article  CAS  Google Scholar 

  11. Raggi, F. et al. Front. Immunol. 8, 1097 (2017).

    Article  Google Scholar 

  12. Flierl, M. A. et al. Nature 449, 721–725 (2007).

    Article  CAS  Google Scholar 

  13. Weber, B. et al. PLoS Pathog. 10, e1003900 (2014).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. German Center for Neurodegenerative Diseases (DZNE)-Ulm, Ulm, Germany

    Francesco Roselli

  2. Neurozentrum Ulm, Ulm, Germany

    Francesco Roselli

  3. Institute of Clinical and Experimental Trauma Immunology, Ulm University Hospital Ulm, Ulm, Germany

    Markus Huber-Lang

Authors
  1. Francesco Roselli
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  2. Markus Huber-Lang
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Correspondence to Markus Huber-Lang.

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The authors declare no competing interests.

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Roselli, F., Huber-Lang, M. TREM1-ors shake the brain and gut after stroke. Nat Immunol 20, 950–952 (2019). https://doi.org/10.1038/s41590-019-0443-9

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