The cytokine IL-15 controls the homeostasis and activation of CD8+ T cells and natural killer cells. A new study reveals the deubiquitinase Otub1 to be a negative regulator of IL-15 signaling, with important consequences for autoimmunity and anti-cancer immunity.
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Moynagh, P.N. IL-15 in autoimmunity and cancer: O-tu-b or not O-tu-b?. Nat Immunol 20, 780–782 (2019). https://doi.org/10.1038/s41590-019-0424-z
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DOI: https://doi.org/10.1038/s41590-019-0424-z
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