Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

HIV IMMUNITY

A SNP of lncRNA gives HIV-1 a boost

Nature Immunology volume 20, pages 778–780 (2019)Cite this article

Subjects

Although the molecular basis of most disease-associated single-nucleotide polymorphisms has remained elusive, an HIV-1 viral load–associated polymorphism (rs1015164) has been identified that marks expression of a long non-coding RNA that regulates the co-receptor CCR5 and thereby influences infection of CD4+ T cells.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Molecular basis for the association of the SNP rs1015164A/G with HIV-1 disease progression.

References

  1. Vangelista, L. & Vento, S. Front. Immunol. https://doi.org/10.3389/fimmu.2017.01981 (2018).

  2. Kulkarni, S. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0406-1 (2019).

    Article  CAS  Google Scholar 

  3. McLaren, P. J. et al. Proc. Natl. Acad. Sci. USA 112, 14658–14663 (2015).

    Article  CAS  Google Scholar 

  4. Noh, J. H., Kim, K. M., McClusky, W. G., Abdelmohsen, K. & Gorospe, M. Wiley Interdiscip. Rev. RNA 9, e1471 (2018).

    Article  Google Scholar 

  5. Cornella, N. et al. J. Biol. Chem. 292, 19674–19692 (2017).

    Article  CAS  Google Scholar 

  6. Mozzi, A., Pontremoli, C. & Sironi, M. Infect. Genet. Evol. 66, 286–307 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA

    Sanath Kumar Janaka & David T. Evans

  2. Wisconsin National Primate Research Center, Madison, WI, USA

    David T. Evans

Authors
  1. Sanath Kumar Janaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David T. Evans
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David T. Evans.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Janaka, S.K., Evans, D.T. A SNP of lncRNA gives HIV-1 a boost. Nat Immunol 20, 778–780 (2019). https://doi.org/10.1038/s41590-019-0422-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-019-0422-1

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing