Supplementary Figure 8: IRE1α-driven NK cell expansion is associated with the presence of immune cell types beneficial to tumor control. | Nature Immunology

Supplementary Figure 8: IRE1α-driven NK cell expansion is associated with the presence of immune cell types beneficial to tumor control.

From: The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc

Supplementary Figure 8

(a) Representative flow cytometric plots and quantification of basal levels of NK cell numbers and relative percentage and Ki-67 and c-Myc expression in the lungs of naïve IRE1NK and IRE1f/f littermate control mice. (b) Gating strategy for c. (c) Percentage of conventional type 1 dendritic cells (cDC1) (left), CD8+ T cells (middle), and CD4+ T cells (right) in the lung and spleen of IRE1NK and IRE1f/f littermate control mice at day 20 following intravenous injection of B16F10 melanoma cells. * p < 0.05, ** p < 0.01. Two tailed unpaired Student’s t-test performed on c. All error bars, mean with s.e.m. n = 4 mice/group for a and 5 mice/group for c. Data were independently repeated three times.

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