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B CELL SIGNALING

GC B cells ‘AKT’ to blunt BCR signaling

A novel feedback loop coordinated by germinal center–specific signaling via the kinase AKT activates negative regulators of upstream BCR signaling to attenuate responses to antigen stimulation.

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References

  1. 1.

    Luo, W. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0376-3 (2019).

  2. 2.

    Mesin, L., Ersching, J. & Victora, G. D. Immunity 45, 471–482 (2016).

  3. 3.

    Natkanski, E. et al. Science 340, 1587–1590 (2013).

  4. 4.

    Victora, G. D. et al. Cell 143, 592–605 (2010).

  5. 5.

    Khalil, A. M., Cambier, J. C. & Shlomchik, M. J. Science 336, 1178–1181 (2012).

  6. 6.

    Mueller, J., Matloubian, M. & Zikherman, J. J. Immunol. 194, 2993–2997 (2015).

  7. 7.

    Luo, W., Weisel, F. & Shlomchik, M. J. Immunity 48, 313–326.e315 (2018).

  8. 8.

    Browne, C. D., Del Nagro, C. J., Cato, M. H., Dengler, H. S. & Rickert, R. C. Immunity 31, 749–760 (2009).

  9. 9.

    Smith, M. J. et al. JCI Insight 4, e123384 (2019).

  10. 10.

    Nowosad, C. R., Spillane, K. M. & Tolar, P. Nat. Immunol. 17, 870–877 (2016).

  11. 11.

    Turner, J. S., Ke, F. & Grigorova, I. L. Cell Rep. 25, 1395–1403.e1394 (2018).

  12. 12.

    Kuraoka, M. et al. Immunity 44, 542–552 (2016).

  13. 13.

    Tas, J. M. et al. Science 351, 1048–1054 (2016).

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The author declares no competing interests.

Correspondence to Julie Zikherman.

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Fig. 1: BCR signaling is rewired in GC B cells to introduce a negative feedback loop.