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B CELL SIGNALING

GC B cells ‘AKT’ to blunt BCR signaling

Nature Immunology volume 20, pages 671–674 (2019)Cite this article

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A novel feedback loop coordinated by germinal center–specific signaling via the kinase AKT activates negative regulators of upstream BCR signaling to attenuate responses to antigen stimulation.

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Fig. 1: BCR signaling is rewired in GC B cells to introduce a negative feedback loop.

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Authors and Affiliations

  1. Division of Rheumatology, Rosalind Russell and Ephraim P. Engleman Arthritis Research Center, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA

    Julie Zikherman

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  1. Julie Zikherman
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Correspondence to Julie Zikherman.

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The author declares no competing interests.

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Zikherman, J. GC B cells ‘AKT’ to blunt BCR signaling. Nat Immunol 20, 671–674 (2019). https://doi.org/10.1038/s41590-019-0384-3

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