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GENE REGULATION

Old dog PU.1 reveals new tricks

The transcription factor PU.1 is not needed for the maintenance of neutrophil identity but is essential for the prevention of excessive tissue damage due to a prolonged immune response. PU.1 restrains the activation of neutrophils by antagonizing the AP-1 transcription factor JunB.

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The author declares no competing interests.

Correspondence to Richard Dahl.

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Fig. 1: PU.1 represses transcription in neutrophils through chromatin modifications that deny access to AP-1 transcription factors.