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CACHEXIA

Not the usual suspect: type I interferon–responsive T cells drive infection-induced cachexia

Cachexia is a reversible feature of inflammatory states that can become maladaptive in many diseases. A new study reveals a role for type I interferons on CD8+ T cells in mediating cachexia during viral infection.

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References

  1. 1.

    Wang, A. et al. Cell 166, 1512–1525.e1512 (2016).

  2. 2.

    Weis, S. et al. Cell 169, 1263–1275.e1214 (2017).

  3. 3.

    Rao, S. et al. Cell 168, 503–516.e512 (2017).

  4. 4.

    Baazim, H. Nat. Immunol. https://doi.org/10.1038/s41559-019-0397-y (2019).

  5. 5.

    Saper, C. B., Romanovsky, A. A. & Scammell, T. E. Nat. Neurosci. 15, 1088–1095 (2012).

  6. 6.

    Longo, V. D. & Mattson, M. P. Cell Metab. 19, 181–192 (2014).

  7. 7.

    Yang, X., Zhang, X., Heckmann, B. L., Lu, X. & Liu, J. J. Biol. Chem. 286, 40477–40485 (2011).

  8. 8.

    Zhou, J., Liu, B., Liang, C., Li, Y. & Song, Y. H. Trends Endocrinol. Metab. 27, 335–347 (2016).

  9. 9.

    Memon, R. A., Feingold, K. R., Moser, A. H., Doerrler, W. & Grunfeld, C. Endocrinology 131, 1695–1702 (1992).

  10. 10.

    Dietrich, M. O. & Horvath, T. L. Trends Neurosci. 36, 65–73 (2013).

  11. 11.

    Tsai, V. W. W., Husaini, Y., Sainsbury, A., Brown, D. A. & Breit, S. N. Cell Metab. 28, 353–368 (2018).

  12. 12.

    Wang, A., Luan, H. H. & Medzhitov, R. Science 363, eaar3932 (2019).

  13. 13.

    Gordon, E. B. et al. Proc. Natl Acad. Sci. USA 112, 13075–13080 (2015).

  14. 14.

    Wang, A. et al. Proc. Natl Acad. Sci. USA 115, 11042–11047 (2018).

  15. 15.

    Ferreira, A. et al. Cell 145, 398–409 (2011).

  16. 16.

    Advani, S. M., Advani, P. G., VonVille, H. M. & Jafri, S. H. BMC Cancer 18, 1174 (2018).

  17. 17.

    Talisa, V. B., Yende, S., Seymour, C. W. & Angus, D. C. Front. Immunol. 9, 1502 (2018).

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The authors declare no competing interests.

Correspondence to Andrew Wang or Ruslan Medzhitov.

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Fig. 1: Different inflammatory challenges induce corresponding cachectic states.