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Not the usual suspect: type I interferon–responsive T cells drive infection-induced cachexia

Cachexia is a reversible feature of inflammatory states that can become maladaptive in many diseases. A new study reveals a role for type I interferons on CD8+ T cells in mediating cachexia during viral infection.

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Fig. 1: Different inflammatory challenges induce corresponding cachectic states.


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Correspondence to Andrew Wang or Ruslan Medzhitov.

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Wang, A., Medzhitov, R. Not the usual suspect: type I interferon–responsive T cells drive infection-induced cachexia. Nat Immunol 20, 666–667 (2019).

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