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Translate less, prime better, to improve anti-tumor responses

Nature Immunology volume 20, pages 518–520 (2019)Cite this article

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The N6-methyladenosine (m6A) RNA-modification pathway affects numerous aspects of immune responses. A new study now demonstrates that m6A modification of transcripts encoding lysosomal proteases limits the efficiency of tumor-antigen cross-presentation.

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Fig. 1: Regulation of antigen cross-presentation by YTHDF1.

References

  1. Han, D. et al. Nature 566, 270–274 (2019).

    Article  Google Scholar 

  2. Meyer, K. D. & Jaffrey, S. R. Annu. Rev. Cell Dev. Biol. 33, 319–342 (2017).

    Article  CAS  Google Scholar 

  3. Li, H.-B. et al. Nature 548, 338–342 (2017).

    Article  CAS  Google Scholar 

  4. Winkler, R. et al. Nat. Immunol. 20, 173–182 (2019).

    Article  CAS  Google Scholar 

  5. Shi, H. et al. Nature 563, 249–253 (2018).

    Article  CAS  Google Scholar 

  6. Theisen, D. J. et al. Science 362, 694–699 (2018).

    Article  CAS  Google Scholar 

  7. Theisen, D. J. et al. Cancer Immunol. Res. 7, 29–39 (2019).

    PubMed  Google Scholar 

  8. Alloatti, A. et al. J. Exp. Med. 214, 2231–2241 (2017).

    Article  CAS  Google Scholar 

  9. Joffre, O. P., Segura, E., Savina, A. & Amigorena, S. Nat. Rev. Immunol. 12, 557–569 (2012).

    Article  CAS  Google Scholar 

  10. Gros, M. & Amigorena, S. Front. Immunol. 10, 41 (2019).

    Article  Google Scholar 

  11. Samie, M. & Cresswell, P. Nat. Immunol. 16, 729–736 (2015).

    Article  CAS  Google Scholar 

  12. Kreiter, S. et al. Nature 520, 692–696 (2015).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Institut Curie, PSL Research University, INSERM U932, Paris, France

    Marianne Burbage, Marine Gros & Sebastian Amigorena

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  1. Marianne Burbage
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  2. Marine Gros
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  3. Sebastian Amigorena
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Correspondence to Sebastian Amigorena.

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Burbage, M., Gros, M. & Amigorena, S. Translate less, prime better, to improve anti-tumor responses. Nat Immunol 20, 518–520 (2019). https://doi.org/10.1038/s41590-019-0371-8

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