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Translate less, prime better, to improve anti-tumor responses

The N6-methyladenosine (m6A) RNA-modification pathway affects numerous aspects of immune responses. A new study now demonstrates that m6A modification of transcripts encoding lysosomal proteases limits the efficiency of tumor-antigen cross-presentation.

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Fig. 1: Regulation of antigen cross-presentation by YTHDF1.


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Correspondence to Sebastian Amigorena.

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Burbage, M., Gros, M. & Amigorena, S. Translate less, prime better, to improve anti-tumor responses. Nat Immunol 20, 518–520 (2019).

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