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CROSS-PRESENTATION

Translate less, prime better, to improve anti-tumor responses

Nature Immunology volume 20, pages 518–520 (2019)Cite this article

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The N6-methyladenosine (m6A) RNA-modification pathway affects numerous aspects of immune responses. A new study now demonstrates that m6A modification of transcripts encoding lysosomal proteases limits the efficiency of tumor-antigen cross-presentation.

Only a minority of cellular proteins are exposed on the surface of cells. T cells monitor intracellular fate, including intracellular infection or transformation, for example, through the presentation of protein-derived peptides associated with major histocompatibility complex (MHC) molecules. These peptides, of precise lengths, are generated intracellularly by controlled proteolysis, and the mechanisms that regulate this process are critical to the homeostasis and function of the immune system. In a study published in Nature, Han et al. now describe a previously overlooked mechanism for the regulation of antigen degradation with direct consequences for antigen cross-presentation and anti-tumor immune responses1.

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Fig. 1: Regulation of antigen cross-presentation by YTHDF1.

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Authors and Affiliations

  1. Institut Curie, PSL Research University, INSERM U932, Paris, France

    Marianne Burbage, Marine Gros & Sebastian Amigorena

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  1. Marianne Burbage
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  2. Marine Gros
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  3. Sebastian Amigorena
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Correspondence to Sebastian Amigorena.

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Burbage, M., Gros, M. & Amigorena, S. Translate less, prime better, to improve anti-tumor responses. Nat Immunol 20, 518–520 (2019). https://doi.org/10.1038/s41590-019-0371-8

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