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INTERFERON-λ

The IFN-λ Pony Express

The mechanisms by which the cytokine IFN-λ regulates adaptive immune responses are poorly understood. A new study now reveals a novel IFN-λ-mediated signal-transmission system that enhances immunity after infection of the mouse respiratory tract with influenza virus.

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References

  1. 1.

    Hoffmann, H. H., Schneider, W. M. & Rice, C. M. Trends Immunol. 36, 124–138 (2015).

  2. 2.

    Levy, D. E., Marié, I. J. & Durbin, J. E. Curr. Opin. Virol. 1, 476–486 (2011).

  3. 3.

    Ye, L. et al. Nat. Immunol. https://doi.org/10.1038/s41590-019-0345-x (2019).

  4. 4.

    Van Roey, G. A., Arias, M. A., Tregoning, J. S., Rowe, G. & Shattock, R. J. Eur. J. Immunol. 42, 353–363 (2012).

  5. 5.

    Kim, D. Y. et al. J. Immunol. 186, 4253–4262 (2011).

  6. 6.

    Sage, P. T. & Sharpe, A. H. Immunol. Rev. 271, 246–259 (2016).

  7. 7.

    Morrow, M. P. et al. Blood 113, 5868–5877 (2009).

  8. 8.

    Syedbasha, M. & Egli, A. Front. Immunol. 8, 119 (2017).

  9. 9.

    Sommereyns, C., Paul, S., Staeheli, P. & Michiels, T. PLoS Pathog. 4, e1000017 (2008).

  10. 10.

    de Groen, R. A., Groothuismink, Z. M., Liu, B. S. & Boonstra, A. J. Leukoc. Biol. 98, 623–630 (2015).

  11. 11.

    Lasfar, A. et al. Cancer Res. 66, 4468–4477 (2006).

  12. 12.

    Heim, M. H., Bochud, P. Y. & George, J. J. Hepatol. 65, S22–S32 (2016).

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The authors declare no competing interests.

Correspondence to Stefan F. Wieland.

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Fig. 1: Regulation of immune cells by IFN-λ.