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T CELL DEVELOPMENT

SLAM-ing the brakes on iNKT cell selection

Members of the SLAM family of receptors promote the progression of invariant natural killer T cells through the thymic maturation process and facilitate proper host responses to exogenous lipid antigen through the recruitment and activity of SAP–Fyn and SHP-1, respectively.

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The authors declare no competing interests.

Correspondence to Shankar S. Iyer or Richard S. Blumberg.

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Fig. 1: SFR-mediated interactions between thymic progenitor cells mediate proper expansion and maturation of iNKT cells.