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IMMUNOMETABOLISM

NAD-biosynthetic pathways regulate innate immunity

Recent studies indicate that macrophages utilize NAD+-biosynthetic pathways to control inflammation and cell survival during the immune response and aging.

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Fig. 1: NAD+ pathways that control macrophage dependent inflammation.

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Correspondence to Navdeep S. Chandel.

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Billingham, L.K., Chandel, N.S. NAD-biosynthetic pathways regulate innate immunity. Nat Immunol 20, 380–382 (2019). https://doi.org/10.1038/s41590-019-0353-x

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