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IMMUNOMETABOLISM

NAD-biosynthetic pathways regulate innate immunity

Nature Immunology volume 20, pages 380–382 (2019)Cite this article

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Recent studies indicate that macrophages utilize NAD+-biosynthetic pathways to control inflammation and cell survival during the immune response and aging.

Nicotinamide adenine dinucleotide (NAD+) biology has garnered much attention over the past few years. A decrease in NAD+ abundance has been linked to many age-related diseases and is associated with changes in metabolism that alter cellular function1. Activation of macrophages is accompanied by distinct metabolic changes that are necessary to drive their pro-inflammatory state2. Therefore, many strategies for boosting NAD+ levels have piqued interest as a means by which to diminish inflammation and pathologies incurred during normal aging3. Minhas et al.4 and Cameron et al.5 have now demonstrated the necessity of de novo NAD+ synthesis in macrophage-driven inflammation during aging, as well as the importance of the NAD+ salvage pathway for maintenance of the pro-inflammatory state.

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Fig. 1: NAD+ pathways that control macrophage dependent inflammation.

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Authors and Affiliations

  1. Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Leah K. Billingham & Navdeep S. Chandel

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  1. Leah K. Billingham
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  2. Navdeep S. Chandel
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Correspondence to Navdeep S. Chandel.

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The authors declare no competing interests.

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Billingham, L.K., Chandel, N.S. NAD-biosynthetic pathways regulate innate immunity. Nat Immunol 20, 380–382 (2019). https://doi.org/10.1038/s41590-019-0353-x

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