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Regulatory T cell adaptation in the intestine and skin

Abstract

The intestine and skin are distinct microenvironments with unique physiological functions and are continually exposed to diverse environmental challenges. Host adaptation at these sites is an active process that involves interaction between immune cells and tissue cells. Regulatory T cells (Treg cells) play a pivotal role in enforcing homeostasis at barrier surfaces, illustrated by the development of intestinal and skin inflammation in diseases caused by primary deficiency in Treg cells. Treg cells at barrier sites are phenotypically distinct from their lymphoid-organ counterparts, and these ‘tissue’ signatures often reflect their tissue-adapted function. We discuss current understanding of Treg cell adaptation in the intestine and skin, including unique phenotypes, functions and metabolic demands, and how increased knowledge of Treg cells at barrier sites might guide precision medicine therapies.

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Correspondence to Fiona Powrie.

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Fig. 1: Treg cell development and subsets in the intestine and skin.
Fig. 2: Host and environmental pathways that shape intestinal Treg cells.
Fig. 3: Treg cell functions in the intestine and skin.
Fig. 4: Host and environmental pathways that shape skin Treg cells.
Fig. 5: Model for the metabolic adaptation of Treg cells at barrier sites.