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MEMORY T CELLS

Pre-birth memory

The transition of the fetus from the womb to the external world represents an extraordinary challenge. The generation of memory T cells before birth may serve an important role in preparation for this fundamental transition.

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References

  1. 1.

    Li et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0294-9 (2019).

  2. 2.

    Li, N. et al. J. Exp. Med. 215, 1383–1396 (2018).

  3. 3.

    Senda, T. et al. Mucosal Immunol. https://www.nature.com/articles/s41385-018-0110-8 (2018).

  4. 4.

    Thome, J. J. et al. Nat. Med. 22, 72–77 (2016).

  5. 5.

    Hegazy, A. N. et al. Gastroenterology 153, 1320–1337 (2017).

  6. 6.

    Zhang, X. et al. Sci. Transl. Med. 6, 238ra272 (2014).

  7. 7.

    McGovern, N. et al. Nature 546, 662–666 (2017).

  8. 8.

    Aagaard, K. et al. Sci. Transl. Med. 6, 237ra265 (2014).

  9. 9.

    Kinder, J. M., Stelzer, I. A., Arck, P. C. & Way, S. S. Nat. Rev. Immunol. 17, 483–494 (2017).

  10. 10.

    Bunker, J. J. et al. Science 358, eaan6619 (2017).

  11. 11.

    Su, L. F., Kidd, B. A., Han, A., Kotzin, J. J. & Davis, M. M. Immunity 38, 373–383 (2013).

  12. 12.

    Byrne, J. A., Stankovic, A. K. & Cooper, M. D. J. Immunol. 152, 3098–3106 (1994).

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Correspondence to Yasmine Belkaid.

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Fig. 1: Naive and memory-like CD4+ T cells accumulate within the fetal intestine.