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Pre-birth memory

The transition of the fetus from the womb to the external world represents an extraordinary challenge. The generation of memory T cells before birth may serve an important role in preparation for this fundamental transition.

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Fig. 1: Naive and memory-like CD4+ T cells accumulate within the fetal intestine.


  1. Li et al. Nat. Immunol. (2019).

    Article  PubMed  Google Scholar 

  2. Li, N. et al. J. Exp. Med. 215, 1383–1396 (2018).

    Article  CAS  Google Scholar 

  3. Senda, T. et al. Mucosal Immunol. (2018).

  4. Thome, J. J. et al. Nat. Med. 22, 72–77 (2016).

    Article  CAS  Google Scholar 

  5. Hegazy, A. N. et al. Gastroenterology 153, 1320–1337 (2017).

    Article  CAS  Google Scholar 

  6. Zhang, X. et al. Sci. Transl. Med. 6, 238ra272 (2014).

    Article  Google Scholar 

  7. McGovern, N. et al. Nature 546, 662–666 (2017).

    Article  CAS  Google Scholar 

  8. Aagaard, K. et al. Sci. Transl. Med. 6, 237ra265 (2014).

    Google Scholar 

  9. Kinder, J. M., Stelzer, I. A., Arck, P. C. & Way, S. S. Nat. Rev. Immunol. 17, 483–494 (2017).

    Article  CAS  Google Scholar 

  10. Bunker, J. J. et al. Science 358, eaan6619 (2017).

    Article  Google Scholar 

  11. Su, L. F., Kidd, B. A., Han, A., Kotzin, J. J. & Davis, M. M. Immunity 38, 373–383 (2013).

    Article  CAS  Google Scholar 

  12. Byrne, J. A., Stankovic, A. K. & Cooper, M. D. J. Immunol. 152, 3098–3106 (1994).

    CAS  PubMed  Google Scholar 

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Correspondence to Yasmine Belkaid.

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Lim, A.I., Harrison, O.J. & Belkaid, Y. Pre-birth memory. Nat Immunol 20, 254–256 (2019).

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