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RHEUMATOID ARTHRITIS

N-myristoylation of AMPK controls T cell inflammatory function

In patients with rheumatoid arthritis, decreased abundance of the N-myristoyltransferase NMT1 in CD4+ T cells prevents N-myristoylation of the AMP-activated protein kinase AMPK and its localization to the lysosomal membrane, which leads to increased activation of the metabolic checkpoint kinase complex mTORC1 and proinflammatory T cell phenotypes.

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Fig. 1: Reduced abundance of NMT1 in CD4+ T cells from patients with RA leads to unrestrained mTORC1 activity.

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Correspondence to David K. Finlay.

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Finlay, D.K. N-myristoylation of AMPK controls T cell inflammatory function. Nat Immunol 20, 252–254 (2019). https://doi.org/10.1038/s41590-019-0322-4

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