In patients with rheumatoid arthritis, decreased abundance of the N-myristoyltransferase NMT1 in CD4+ T cells prevents N-myristoylation of the AMP-activated protein kinase AMPK and its localization to the lysosomal membrane, which leads to increased activation of the metabolic checkpoint kinase complex mTORC1 and proinflammatory T cell phenotypes.
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Udenwobele, D. I. et al. Front. Immunol. 8, 751 (2017).
Wen, Z. et al. Nat. Immunol. https://doi.org/10.1038/s41590-018-0296-7 (2019).
Rampoldi, F. et al. J. Immunol. 195, 4228–4243 (2015).
Weyand, C. M., Zeisbrich, M. & Goronzy, J. J. Curr. Opin. Immunol. 46, 112–120 (2017).
Oakhill, J. S. et al. Proc. Natl Acad. Sci. USA 107, 19237–19241 (2010).
Zhang, C. S. et al. Cell Metab. 20, 526–540 (2014).
Lin, S. C. & Hardie, D. G. Cell Metab. 27, 299–313 (2018).
Bruyn, G. A. et al. Ann. Rheum. Dis. 67, 1090–1095 (2008).
Deng, L. et al. Cell Death Dis. 9, 1143 (2018).
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Finlay, D.K. N-myristoylation of AMPK controls T cell inflammatory function. Nat Immunol 20, 252–254 (2019). https://doi.org/10.1038/s41590-019-0322-4
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