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Revisiting the old and learning the new of zinc in immunity

The zinc transporter ZIP7 positively regulates signaling via the BCR during early B cell development in mice and humans. Impairment of ZIP7 function results in a novel primary immunodeficiency.

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Fig. 1: ZIP7-mediated modulation of BCR signaling through its control of the zinc signaling axis.


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Correspondence to Toshiyuki Fukada.

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Fukada, T., Hojyo, S., Hara, T. et al. Revisiting the old and learning the new of zinc in immunity. Nat Immunol 20, 248–250 (2019).

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