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Alarming eosinophils to combat tumors

Combined immunotherapy using checkpoint blockade (anti-CTLA4 and anti-PD-1) and the DPP4 inhibitor sitagliptin reveals the existence of a T cell– and eosinophil-targeted immunotherapy approach for solid tumors.

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Fig. 1: Inhibition of DPP4 elicits an eosinophil-dependent anti-tumor immune response.


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Correspondence to Simon Patrick Hogan.

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Munitz, A., Hogan, S.P. Alarming eosinophils to combat tumors. Nat Immunol 20, 250–252 (2019).

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