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CANCER IMMUNOLOGY

Alarming eosinophils to combat tumors

Nature Immunology volume 20, pages 250–252 (2019)Cite this article

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Combined immunotherapy using checkpoint blockade (anti-CTLA4 and anti-PD-1) and the DPP4 inhibitor sitagliptin reveals the existence of a T cell– and eosinophil-targeted immunotherapy approach for solid tumors.

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Fig. 1: Inhibition of DPP4 elicits an eosinophil-dependent anti-tumor immune response.

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Authors and Affiliations

  1. Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Ariel Munitz

  2. Mary H Weiser Food Allergy Center, Department of Pathology, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA

    Simon Patrick Hogan

Authors
  1. Ariel Munitz
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  2. Simon Patrick Hogan
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Correspondence to Simon Patrick Hogan.

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Munitz, A., Hogan, S.P. Alarming eosinophils to combat tumors. Nat Immunol 20, 250–252 (2019). https://doi.org/10.1038/s41590-019-0318-0

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