Supplementary Figure 6: Progenitor exhausted CD8+ T cells have greater persistence than that of terminally exhausted CD8+ T cells. | Nature Immunology

Supplementary Figure 6: Progenitor exhausted CD8+ T cells have greater persistence than that of terminally exhausted CD8+ T cells.

From: Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Supplementary Figure 6

a, Cell numbers/mg tumor of transferred (CD45.2+) progenitor or terminally exhausted cells in recipient tumors. Summary of two of three independent experiments, n = 16 (progenitor exh.) or 17 (terminally exh.) mice. b, Frequency of transferred progenitor exhausted or terminally exhausted cells in draining lymph nodes of recipient mice. Summary of two independent experiments, n = 16 (progenitor exh.) or 17 (terminally exh.) mice. c, Frequency of transferred progenitor or terminally exhausted cells in lymph nodes from in vivo persistence assay mice without tumor implantation (Supplementary Fig. 5c). Summary of two independent experiments, n = 7 mice. d, GSEA of central vs. effector memory signature (GSE23321) in the ranked list of genes differentially expressed by progenitor exhausted vs. terminally exhausted from B16-OVA tumors (left) or ranked list of genes differentially expressed by a second, independent dataset of central memory versus effector memory cells (GSE98640), for comparison. FDR shown for each comparison calculated by gene set permutation test. Mean +/- s.d. (a-c); two-sided Student’s t test (a-c); * p ≤ 0.05,**** p ≤ 0.0001.

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