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CIRCling the wagons to protect intestinal stem cells

Innate lymphoid cell–derived cytokine IL-13 promotes the maintenance of intestinal stem cells through stabilization of β-catenin. The circular RNA circPan3 regulates mRNA encoding the cytokine receptor subunit IL-13Rα and downstream IL-13 signaling to stabilize the β-catenin pathway in intestinal stem cells.

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Fig. 1: Role of circPan3 in ISC regulation.


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Correspondence to Ram Savan.

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Soveg, F., von Moltke, J. & Savan, R. CIRCling the wagons to protect intestinal stem cells. Nat Immunol 20, 114–116 (2019).

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